I know nothing about IT project management for healthcare, but just the other day over here in the local news there was a mention that the all-singing-all-dancing healthcare application that the region (with ~1M inhabitants) has been spending years and around 800 million euros to get into production has been so poorly received that they're considering starting over from scratch. I'm so happy seeing my tax money well spent...
This is an implementation of something called MUMPS, which is apparently some US system that is very arcane but widely used.
Again, I'm not an expert on this topic, but it indeed seems like standards, API's, file formats and whatnot would be keys to a system where decoupled components can be evolved step-by-step over time instead of the current system which seems to be a humongous monolith.
Which sounds crazy to me considering how much involvement the US has with FHIR.
http://hl7.org/fhir/
Even if you don't care about this stuff, FHIR is definitely worth investigating.