Definitely, I've had a mosquito hit me while flying and you can actually feel it hit your skin.

The subject of this story is a single proton that you would definitely feel if it hit you: https://www.fourmilab.ch/documents/OhMyGodParticle/

I don't think that is the case. The kinetic energy of these super-energetic particles is often compared to a tennis ball. But that energy isn't released at once, so even if it would interact with yourself, that interaction creates a particle shower that takes most of the energy with it. I don't think we can feel one of our atoms getting violently ripped apart.

There’s Anatoli Bugorski [1] who accidentally put his head into the path of a high energy proton beam.

The injury resembled nothing like being hit by tennis balls.

> He reportedly saw a flash "brighter than a thousand suns" but did not feel any pain.

He’s still alive today, age 83.

[1] https://en.wikipedia.org/wiki/Anatoli_Bugorski

Which kind of mosquito? European or Asian?