I’m not a particularly skilled overwatch player, but I know the cooldowns of probably half the characters to muscle memory. I can hit an ability pretty much perfectly on cooldown 90+% of the time.

The vast, vast majority of skilled FPS players will predict their shots and shoot where they think the enemy player will be relative to the known hit detection of the game. In high level play for something like r6 siege, I’d say it’s 99% shooting before you can possibly know where they are by “feeling”