I was in a similar situation. While I'm very much an introvert, the emptiness you mention became very strong.

I changed a few things to improve. I started riding a bike, and I joined some local casual bike riding meet-ups in the weekends. The meet-ups had a lit of new people each time as well as some frequent members, so I could usually choose between just riding along, talk to someone familiar or talk to someone new. After a bit I got some new friends this way which I met outside of the meet-up.

I picked up a couple of weekday activities. For one I went for something that interested me, but also was fairly casual and had natural dead time which allowed for talk. Bowling, darts, frisbee golf, that sort of thing. For the other I went with something that helped others. In my case they had an after-hours activity at a local school helping kids start programming.

I also played a lot of games before and after, mostly single player or just random multiplayer, but I ended up getting into a MMO and finding a guild. This became the primary place I'd hang out and talk about pork chops and broken blinds.

It wasn't a quick fix, but by working at it the emptiness faded.

A big difference was I had an office to come to with colleagues to talk to. We have a couple remote workers as well, and both of them have gotten an office space in a shared office building. This way they still get to eat lunch with someone or hang out by the coffee machine.

Best of luck and hang in there.