Generally you'll have your drive only unlock against certain PCRs and their values. It depends on which PCRs you select and then how exactly they are measured.
E.g. systemd measures basically everything that is part of the boot process (kernel, kernel cli, initrd, ...[1]) into different PCRs, so if any of those are different they result in differen PCR values and won't unlock the boot device (depending on which PCRs you decided to encrypt against). I forgot what excatly it measures, but I remember that some PCRs also get measured during the switch_root operation from initrd -> rootfs which can be used to make something only unlock in the initrd.