Yes, the distances are mind-boggling. There are a few somewhat realistic solutions for making such a trip in the forseeable future. If you send something of significant mass, it is certain to take a long time. So we're either talking generation ships(§), embryo space colonization (growing into adults en route or at destination) or hibernation. That or a breakthrough in fundamental physics.
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(§) Something like O'Neill cylinders with fusion as energy source could work
This old video is a beautiful and astounding demonstration of just how vastly, hugely, mind-bogglingly big the Universe is, and where in all this endless space our dear favourite little Pale Blue Dot (Earth) resides:
https://m.youtube.com/watch?v=X-3Oq_82XNA
We all Earthlings are extremely lucky to be alive and thriving (or trying to) in such a beautiful bountiful rarest-of-rare ecosystem that somehow survived and thrived despite all the vagaries and vastness of spacetime.
I think the video I have linked above is Google's tribute to this Power Of Ten video (linked below, thanks to user dtgriscom for sharing the link in another comment), a classic video that demonstrates the scale of the Universe from the micro to the macro perspectives in a scaling increase by a factor of ten for each scene.
Power of 10: https://www.youtube.com/watch?v=0fKBhvDjuy0
Another relevant video (thanks to user christev for sharing the link): A Brief History of Geologic Time: https://youtu.be/rWp5ZpJAIAE
Absolutely humbling to realise how infinitesimally small and irrelevant our existence is, in the grand scheme of theme. Nature and science are amazing.
Add this one to your pile:
https://www.youtube.com/watch?v=KEHCCsFFIuY