The servers I use ZFS on are Debian, so it’s well supported in that way. I’m pretty sure ZFS on Debian uses dkms, so if you want to try it on a data partition, it will work.

Still, unless you want to tinker with something new I can’t really recommend it. Would it work? Yes. Do you need it? No. You’re probably fine with whatever FS you currently have running. ZFS works on Debian, but it’s not first-party support (due to licensing). Do I think you’d have issues if you wanted to try it? Probably not. I’m just conservative in what I’d recommended for a daily use machine. I prioritize working over everything else, so I’d hate for you to try it and end up with a non working system.

Here’s what I’d recommend instead - try it in a VM first. See if you can get it to work in a system setup like yours. See if it’s something that you like. If you want to use it on your primary machine, then you’ll be able to make a more informed decision.