Very simple. Some of the applications work with the "console/allow all" trick (which is a tedious procedure, but hey, I'm just a dumb customer), others still don't work but crash and give strange errors that some stuff could not be accessed. But none works immediately. On systems older than Sequoia, everything works as expected (I just have to start them via the context Open menu, which is ok).
...do you have any actual errors to showcase here? This all seems very odd to me and unlike anything I've ever experienced.
There are quite many given that I only started using Sequoia a few weeks ago, and all happen only on Sequoia, not on my other macOS versions. A nasty one I discovered last week is e.g. that I have to delete and re-add an application (which generates key events for the operating system) to Privacy/Accessibility each time I re-compile it, otherwise the events are simply swallowed without any error. If you happen to be an Apple representative, we can continue by email.