I'd suggest Clojure simply because of the JVM. The JVM is unjustly maligned, and I will defend it to anyone at any time. Having access to the huge Java JAR ecosystem for integrations and libraries is a game changer compared to CL.

As for interactivity - I use a REPL daily with Clojure and it works just as you'd expect from a CL REPL. The only time you need to reload is if you add a new JAR to the classpath or occasionally when state gets really weird. There are reload facilities baked in to nREPL too.

For reference, I've used Clojure professionally for about a decade.

I'd suggest trying it out with Calva in VS Code.