iirc folding spacetime was a separate (and unexplained) piece of magic; what the spice did was to let you navigate a ship through folded space, which unenhanced human perception could not do.

but specifics apart, the main point is just because readers accept hyperspace and extrasensory perception as part of your fictional universe, doesn't mean they will not expect the laws of thermodynamics, or planetary ecology, or other related fields, to also be suspended.