It doesn't play nice with a lot of popular Python libraries. In particular, many popular Python libraries (NumPy, Pandas, TensorFlow, etc.) rely on CPython’s C API which can cause issues.

FWIW, PyPy supports NumPy and Pandas since at least v5.9.

That said, of all the reasons stated here, it's why I don't primarily use PyPy (lots of libraries still missing)

But pypy doesn’t necessarily perform as well, and it can’t jit compile the already compiled C code in numpy, so any benefits are often lost.