I never thought too much about what you just said — specifically about web interfaces and their single-window nature — but now that you mention it, a lot has changed as a direct result.
I think of an app like Photoshop, and it had one window for each image you had open, and then floating toolbars, another window for layers, etc. You could really organize your workspace and have a sense of "mise en place" in a way that doesn't really exist anymore.
Now every application is essentially a 16:9 rectangle squeezed into a tab. The web's enabled some amazing things, but not at zero cost…
Something's lost but something's gained, in living every day.