A fair few things want blob object storage like S3. NFS does not scale to ridiculous levels horizontally or vertically. S3 does things like de-duplication and other funky tricks.

So if you want to use an app that needs S3 then you need to deploy S3 and not NFS.

I run a minio cluster (S3) for Veeam backups at work. I also run multiple NFS for Veeam and VMware datastores.

Tools for the job mate!