It's been a few years since I last looked at it, but I've tried daily running it probably 4 or 5 times over the last 15 years. Usually on Arch, but also some Debian/Ubuntu-based distros. It's fuzzy now but I've tried probably every NVIDIA GPU generation since the GTX 500 series.
I can't remember all the bugs, but I've definitely at least encountered all flavors of flickering bugs, stale updates, GPU crashes, failed copy and paste, failed screenshares, failed videoconferences...
From comments on this thread, it sounds like things have drastically improved and its probably time to take another look.
The version of NVIDIA drivers that Debian ships with lacks explicit sync even now. Pretty much every other distro should work though.