Not really. Have spare drives on the shelf and use the "remote-hands" feature from the CoLo provider. Just open a ticket to have the drive swapped. Pretty easy. For remote server connections just use IPMI/iKVM and iPXE. Again, not too difficult.

The biggest hurdle is getting a mgmt system in place to alert you when something goes wrong - especially at this size. Grafana, Loki, monit, etc are all good tools to leverage that provide quick fault identification.