I think a couple of things have to be untangled here.
The problem we are talking about in both Python and TS comes from the fact that they are (or compile down to) dynamic languages. These aren't issues in statically typed languages... because the code just won't compile it it's wrong and you don't have to worry about getting data from an untyped library.
I don't know a lot about Zod, but I believe the problem you are referring to is more about JavaScript then TS. JavaScript does a LOT of funky stuff at runtime, Python thank God actually enforces some sane type rules at runtime.
My point was not about how these two function at runtime. My point was that if you want to tac static typing onto a dynamic language, Typescripts approach is the better one, but even if can't fix the underlying issues with JS.
You could take a similar approach in Python. We could make a language called Tython, that is statically typed and then compiles down to Python. You eliminate an entire class of bugs at compile time, get a far more reliable experience then the current weirdness with gradual typing and linters, and you still get Pythons runtime type information to deal with things like interopt with existing Python code.