OP did write "fully aligned".
The US is increasingly turning in to a religious state. Most of the Middle East are people who are part of a religion fundamentally in conflict with the religiosity of America and vice versa.
Ridiculous to me as I don't subscribe to any of this, but oh well.
More fundamentally, the people in those places strongly oppose the U.S. regardless of the alliances of their government. They’re religious and hate the U.S. for supporting Israel. They hate the U.S. interventions in middle eastern affairs. They often have strong sympathies towards socialism and hate the U.S. opposition to socialism.