I have never experienced it, myself, but have seen several close friends deal with it.

They always come back wiped out, and sick.

Usually, it’s a temporary thing; meant to keep you going, until a full cure (like a transplant) can be effected.

My friend made his decision, because a transplant was not an option. He would need to live like that, for the rest of his life. I have a couple of other acquaintances, that got transplants, and were able to go past dialysis.