When things like this happen, I think about how during WW1 people talked about the possibility of "bombing a country back to the stone age". Destroy enough libraries, have enough people abandon their areas of specialty employment into different fields, and given enough time, you can erase a society's institutional knowledge and capability.
If we lose enough key resources like the Internet Archive we could definitely shifting the pendulum in that direction.
The siege of Baghdad and the House of Wisdom by the Mongols arguably still affects us today.
And the entire "Dark Ages"?
Dark Ages, maybe not as much since Europe recovered during the Renaissance, but the Middle East hasn't necessarily been too stable since the Islamic Golden Age.
I think it would only be a mild tragedy, if there is such a thing, if, say, we lost 3nm lithography or carbon fiber airplanes. Most of that stuff is luxury anyway. We wouldn't lose the core science and data, it might set us back for a generation which isn't necessarily a bad thing.