You go to Midtown Manhattan and you continue to find plenty of chain stores like Target. Large scale stores are fine. Just don't dedicate space to parking. If you must, use underground parking garages not surface parking lots. You can cater to lots of shoppers if you assume shoppers will walk there or take public transportation.
It's easy to forget the large Department Store started in downtown areas with plentiful multi-story buildings. We tend to remember the few that remain now as the anchors at the ends of malls, but they started as more natural vertical extensions of urban development.