It's a given that if you're taking space exploration seriously, you need ISRU. You can't ship everything to Moon or Mars from Earth - you need to learn how to process and refine local materials.

This is the key advantage of going to Mars or Moon surface, as opposed to operating a space station. A space station exists in a vacuum. Surface bases have access to local materials.

Sadly, very few planned space missions have this kind of ambition. That recent proposal US had about putting a nuclear reactor on the Moon was at least a step in the right direction - if you're bringing an entire reactor, that means you're establishing a permanent base, complete with an industry that would generate the demand for power.