Thanks! However... I am very junior right now lol (<1 YOE)
(I have applied to both competitive as well as more niche firms fwiw, I expect there have been stronger resumes I've "lost to". Though, my degree isn't a "common" one even though it's actually very suitable.)
It's not you. As a junior, there are going to be so many candidates for anything you feel qualified to apply for. It's a numbers game. IMHO, you should still tailor your resume to fit the position. I'd put together a too long resume with everything, and trim off irrelevant stuff so it's down to one page (maybe two, if that's the standard locally) of mostly relevant things for each position; when your resume does get looked at, you want it to pass muster.
Do your best to network. Think about the people you went to school with: who among them would you like to work with.
Every week, send 2-5 of them an email, remind them of what you did in school together, ask them how their summer/etc was, how are they doing at job hunting/if they like the job they found. If you don't mind looking a little desperate, in that email write something like I'm having a hard time getting interviews, have you found anything that works? If you don't wait for their reply... if they got hired, ask if their company is hiring; if they're still looking ask for tips.
Check in with your school's career center. Check in with your favorite professors.
Check in with your parents' friends and your friends' parents.
A personal connection is likely to get your resume looked at closely and not just ignored because there were 1000 applicants and 10 candidates seemed worth interviewing in the first 100, so they didn't look at the rest. It might not get you an interview, but it helps your chances; also, a personal connection might get a referral to an unrelated opening which is unlikely for an unconnected application. I would definitely send a friend's kid to another friend at a different company if I thought that was a potential match, but I wouldn't consider it for a resume that just came in.