I cant agree less. Taking the basic concept of dividing the universe into things that are real, and constructs and blowing it up into a whole hiarchy of values , putting numbers at the top, is only a construct, built on constructs. The current state of science is one where there are a few islands where things work internaly, like how elements are created through certain processes in stars, it's mostly good, but there are exceptions, and then there is a gulf, a vast hand wavy conjectural gulf between that and exactly where the helium came from, or when, or if it did. It is the eternal always almost of bieng poised on the brink of a revelation thats great for suckering in a few more to toil and grind away at the secrets of reality, which they do, and it is from those endevours that some of the best patentable ideas come from.