I’m with the sibling commenter: Python’s heavy-weight-ness and overhead is a thing, yes, but it’s not the same kind of overhead that gets us to power hungry bloated systems—that stuff has more to do with (on the server) wakeups, memory thrashing from async GC, and careless addition of all sorts of background threads/services to applications without considering efficiency. On the desktop, bloat/overhead have more to do with questionable design choices made by UI frameworks, security/container layers that defeat some performance optimizations, and regular bloated browser-in-a-box GUI apps.

Python is a bad choice for high-throughput systems but not for reasons that make it power inefficient when used in a scripting capacity like tuned.