I'm one of those users, but only because I don't need the be on the bleeding edge.
The only problem I had on Debian 11 desktop was related to the new openssh libraries. I could not install the latest nodes and rubies because 11 had older libraries. However there are workarounds related to providing some environment variables (from memory: some legacy_providers_*) so after a little googling I made them work on my dev machine (and on some old server from a customer of mine.) I'm installing Debian 13 in these days so no more workarounds, for a few years.
Everything else worked fine. I don't install much on this machine: no flatpacks, no appimages, no snaps (I left Ubuntu because of them.) Only debs and docker images. I install languages through their language manager, never through the OS: I could have only one version of them, which is useless. Same about databases. There are hardly two projects on the same language and db version. I could be using LibreOffice and GIMP from 20 years ago: they already had all the features I need.
I use incus for my dev needs. But for work computers, I’ve mostly needed one version of everything.