I tried this for pixel art and came away a bit disappointed. It seems to have no real support for drawing using palettes / indexed colors. Sure, you can setup or load a palette, but the drawing tools make no reference to it, and continue to colors outside of it. The color pickers don't even show the palette, they just show the full color wheel. Where is the support for dithered gradients using on palette colors? Where is the support for antialiasing using only palette colors? Maybe this is planned, but given it's already at v2.0 I'm surprised the pixel art support is so half-baked.
It's possible to implement dithering and posterization using the node graph, where you paint normally and it outputs as dithered pixel art in whatever palette you want. It's not a perfect replacement for builtin tools, but still pretty cool. Someone showed their setup for this in the Discord server.
That's cool that you can do that. I worry though that the level of complexity required to set that sort of thing up will act as a hurdle for many that might want to use that feature.
If the node graph is saved in the document (?) perhaps there exists then a "template" (empty document) where the node graph is already set up for palette dithering. That would make it easy to onboard for new users.