I'm not sure how "useful" or "good" the work is. But some one instruction computers have a considerable amount of tooling already in place.

i.e. https://esolangs.org/wiki/FlipJump

Flip Jump is amazing. I understand the theory and how it works but it still amazes me that it does. Things like this is why I love the science in computer science.

And subleq even has a c-compiler and operating system, just wow. https://en.wikipedia.org/wiki/One-instruction_set_computer#S...