If we're still calling Guile a Scheme (I'm out of the loop) then I don't know, it gets really bloody close. Not so much in image-based development (that I've usually found less good than a decent packaging system because the contents of my files on disk is usually more tractable than the contents of my image), but its object system and error handling are definitely up there close to CL.

I mean, Common Lisp is still the gold-standard for me, but reading about Hoot recently really made me want to check Guile out a bit more (CL does not have much in the way of lovely WASM stories right now) and, honestly, I was super impressed. I think if the interactive experience of developing in Hoot in the browser matched the interactive experience of developing in native Guile, I'd be a pretty happy convert.