The inner call to make your work matter is, I think, a good one and something that if we had more of then the world would be in a better place. That being said, I think Ecclesiastes has an important message that has at least saved me quite a lot of trouble.

Nothing we're doing is anything more than variations of things already done and even if we're successful then it's only to the benefit of morons.

So work hard but make sure to take the afternoon off every once and a while to surprise your spouse with flowers and a picnic.