2 years ago, I rode solo from Santa Fe to Seattle (about 1600 miles). The ride crossed some of the emptiest terrain in the lower 48 states of the USA. I have done several significant bike tours in the past, have travelled throughout the west in a powered vehicle and generally know how to look after myself in the wilderness.
I fully expected to face several significant sections where risks where high, notably from lack of water but also just general remoteness.
The reality was quite different. Just the distribution of gas stations meant that water supply was rarely a problem (though I did have a fancy australian 4 liter bottle on my bike and water bladder on my trailer). There was one day when I came close to running out and that was a little scary, but tiny sips and another 12 miles got me to a gas station.
But it wasn't just gas stations. There are not many places in the lower 48 where you can go 40 miles without passing some sort of human habitation if you're on a paved road. The Mojave and parts of Nevada might be an exception. I didn't need to get help from any such places, but I was always aware that I was passing by them.
In addition, sure, some of the most back- of the backroads I took got very little traffic, it was still the case that there would be at least a car every 2 hours or so.
My point is this: if you're travelling on paved roads in the lower 48, you are extremely unlikely to die from mistakes arising from unpreparedness. You might suffer a bit, but you will encounter someone who is very likely to be willing to help you.
One thing I would say, however: in years and decades past, I would never have had any hesitation riding or walking down a farm/ranch driveway if I needed water or help. News events over the last few years involving shootings of "strangers" in driveways now make me extremely reluctant to do such a thing. I contemplated this often on that ride, and if that situation had arisen, my plan was to stay on the road and make as much noise as I could before being OK'ed to cross their property line. A sad change for me, and for the country.