Serotonin can decrease IL-17 production, and IL-17 is highly elevated in depressed patients. Inflammation is elevated in depressed patients more generally, but baseline IL-17 levels specifically appear to be a good predictor for antidepressant response[1]. Anti-depressants are pretty much universally anti-neuroinflammatory.
AFAIK the truth is a little more complex: SSRIs do work for many people, but we don't really understand why and it's not as simple as 'more serotonin good.' They also don't work for everyone, and we don't understand why they don't work for some people either.
“Chemistry literacy” is very poor in the general public because it has very few everyday applications, so everything learnt at school just drops out of people’s brains.
That’s why your hear nonsense like “It has chemicals in it!!!”
It’s also why you regularly see science fiction where characters can grow in seconds, totally breaking the law of conservation of matter.
Serotonin can decrease IL-17 production, and IL-17 is highly elevated in depressed patients. Inflammation is elevated in depressed patients more generally, but baseline IL-17 levels specifically appear to be a good predictor for antidepressant response[1]. Anti-depressants are pretty much universally anti-neuroinflammatory.
[1]: https://pubmed.ncbi.nlm.nih.gov/28698115/
Yes, cytokine like IL 17 increase an enzyme called IDO which pulls tryptophan away from the serotonin production pathway.
https://www.researchgate.net/figure/Effect-of-IDO-on-seroton...
Isoniazid has an antidepressant effect as a weak MAOI, but any interaction with IL-17 would be indirect and related to a reduced microbial load in TB.
in case anyone wondering:
https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i...
That’s a great question
Serotonin has little relevance to depression and was more of a cute story doctors told patients in the '90s, that they were told by pharma reps.
AFAIK the truth is a little more complex: SSRIs do work for many people, but we don't really understand why and it's not as simple as 'more serotonin good.' They also don't work for everyone, and we don't understand why they don't work for some people either.
seratonin is a molecule
this is a protein[1]
this question strikes me as asking if a quark has a relation with an atom
[1] https://en.wikipedia.org/wiki/Interleukin_17
A protein is a molecule What a strange reply
“Chemistry literacy” is very poor in the general public because it has very few everyday applications, so everything learnt at school just drops out of people’s brains.
That’s why your hear nonsense like “It has chemicals in it!!!”
It’s also why you regularly see science fiction where characters can grow in seconds, totally breaking the law of conservation of matter.