COVID was basically an act of god that effected everyone and for whom no single actor could be blamed.
This is the thoughtless incineration of trust in a network of relationships, and that has to be earned back.
It's unclear how long that will take even if the GOP loses the next few presidential elections given how much US policy can change from one term to the next.
The world will be waiting to see if Trumpism ends with Trump or if it becomes something they have to account for possibly taking power every four years.
This has ramifications for any long-term investment into the US like factories and manufacturing. The risk has just shot up and will be much slower to come down.