This is a compelling argument, but I think it's overly pessimistic. Back on the human side, the ending sees Robert adapting to his situation; he loses his left arm (his "sinister"), and it looks like he's lost his wife for good, but he's managed to find some amount of synergy with the new world and technology he's surrounded by. Combined with Rabbit's temporary "defeat" (an experience that, if he's truly a super-intelligence capable of true learning and growth, should lead him to different means and even ends in the future, if nothing else), the implicit conclusion seems to be a future with an imperfect but livable melding of humanity and technology. Not too different from what's come before. Putting all of human history onto a single drive likewise might seem like a diminishing of its significance, but the fact is that it's still there to dive into, should one desire. That's arguably a step up from the past.