The underlying assumption Black-Scholes makes, that stock price movements can be modeled by a log-normal distribution, is known to be false. However not since the 1980s has this lead to the ability to make money of the model itself being imperfect.
The true distribution of the market beliefs in future stock prices can be understood by empirically studying the volatility smile [0]. That is, because investors know Black-Scholes is not a perfect mathematical model of real world stock behavior, every strike price has a different implied volatility. By looking at these different IVs you can get a sense of what the market believes are the true probabilities of "long tail" events.
In theory, the opportunities you have to make money should be cases where you believe the market has mispriced risk. In my amateur experience, I have found that virtually every time you think the market has mispriced some extreme event, when you look at the volatility smile, you realize you are mistaken.