> I know the performance meta in Python is to...not use python (bind to C, Rust, JVM) - and you can get pretty far with that (see: uv), but I'd rather spend my limited time building expertise in a language that isn't constantly hemorrhaging resources unless your code secretly calls something written in another language :/

In case it encourages you: a lot of uv's performance benefits come from things that are not the implementation language. In particular, it has a much more intelligent system for caching downloaded package artifacts, and when asked to pre-compile bytecode it can use multiple cores (this is coming soon to pip, to my understanding; actually the standard library already has a primitive implementation).