Good point about primes, not enough symbols for uniqueness, so just π isn't enough! Though using two symbols ( .* ) in place of nothing is too dirty, better use an invisible and color highlight the spacing between π and ( to indicate to the plain text reader the difference.

Win screenreaders understands 2.3 (pronounced two three) vs 23 (twenty three), though it doesn't pronounce the operator, neither in a.2 vs a2 (though pronounced differently). But this could be fixable, so also good point about accessibility