I followed much of this path as well, but with conda (and mamba) in the mix. They all had fairly obvious flaws that uv doesn’t AFAICT.

Poetry was the worst for me. It doesn’t even try to manage the Python distribution, so it’s only a partial solution. It was so slow our CICD would timeout and fail. And I watched the maintainers actively refuse to fix super annoying bugs for YEARS, blaming others for the problem.