There's plenty of games where either the setup is tedious, or some of the rules create confusion. Game of the year "Wingspan" confused everyone in my group the first time we played, and only made sense after watching a YouTube explanation. A confident system would have been great.

Setting up a game can be tedious as well; Axis and Allies is notorious for taking longer to set up than to play, but it's a lot of fun once you get going.

I actively avoid boardgames with overly long setup times. There's no reason to spend more time prepping than playing if you can play something else with better prep time instead. Time is in limited supply as an adult. If a game needs a digital support device, then there's no reason to waste time on the "board" aspect. Why not just play digital game instead?

Confusing rules can be ok, it depends on how complex they are (as in, what interactions they have). If the confusing rule is mostly self contained, then after playing a few times you'll learn it and it's no longer a problem. If the confusion stems from how the rule interacts with other rules, then it's a much bigger issue since you constantly need to cross-check the rules reference or worse, youtube videos and forums, on what to do.

One of my favorite games, Arkham Horror the card game, has some pretty complicated rules, but as long as they're just part of the player cards or base mechanics you eventually learn them and they become a non-issue.

It's a whole other issue when the complex rules are on specific campaign cards. Each campaign is only played a few times, so that means you never get familiar with the rule and learning it doesn't really "pay off". The campaign experience is lessened because you had to stop the game to check youtube or a forum to resolve the discussion, or just bicker and argue until a consensus is reached nobody is happy with.

As new campaigns get released the complexity of the campaign cards just keeps getting worse, requiring more prep-time as well, and my enjoyment of the game lessens as a result. The first couple of campaigns remain the most enjoyable, even on repeat plays, because they're just easier to explain to new players.