>On a Pico? No

but Yes on pico2 because RP2350 has separate fast serializer (HSTX) hardware block able to clock out at 2x the global clock (DDR). 320MHz OC results in 600Mbit output. Here example pumping out 175 MByte/s of data encoded as HDMI signal (3 lanes) without touching PIOs https://github.com/steve-m/hsdaoh-rp2350 to be used with $6 MS2130 USB 3.0 4k HDMI Video Capture dongle.