I'd be surprised if we saw anything more than the 4x speedup from compiling Python with something like Nuitka/mypyc/etc can bring.
I also believe the JIT in v8 and Python are different, the latter relying on copy-and-patch while v8 uses a bunch of different techniques together.
Obviously dumb microbenchmark, but here's ~17x on my machine:
I think some relatively simple math JITs and compiles nicely like that, but when you start using other parts of the language heavily like you would in a real project, it averages out to about ~4x due to the object, VM and locking model, I believe. It's been a while since I've looked into this.