I think it depends. With tirzepatide (my first encounter with GLP1 meds) I got acute appetite suppression, perhaps too acute. I living comfortably on sometimes 1500 calories or less per day, and I track my calories religiously. We are talking maybe 1 cup of yogurt with frozen berries in the morning, and 1 whey protein shake around 3pm (Fairlife milk + 2 scoops whey) and I would be absolutely full until bed. No energy deficiencies to note. I worked out regularly 5 days a week.

This caused rapid weight loss. A side effect of this rapid weight loss and lack of food intake I also attribute to my thinning hair and dry, splotchy skin outbreaks. Any sort of overeating on tirzepatide (for me) caused severe sickness, or nausea.

Retatrutide, by contrast, causes far less pure appetite suppression (my dosage is also lower) and has another mechanism which helps me maintain leanness while also eating extra calories. I think I prefer the reta, but if I ever felt the need to very simply destroy my appetite again I wouldn't hesitate to use tirzepatide again.

I procured both tirzepatide and retatrutide through the peptide "grey markets" so one was not harder to come by than the other.